circRNA basic information
circBase ID: -
Name: hsa_circ_RNF20
Synonym: -
Host Gene: hsa-miR-487a
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BC cell lines (MCF-7, MDA-MB-468, MDA-MB-231, MDA-MB-453), normal human breast epithelial cell (MCF-10A)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: HIF-1alpha/HK2
Associated microRNA: hsa-miR-487a
Biological function: promoted the proliferation and Warburg effect (aerobic glycolysis) of BC cells
Molecular mechanism: Regulating hsa-miR-487a/HIF-1alpha/HK2
Survival: -
Supported No.:
 1
Description:

circRNF20 harbor miR-487a, acting as miRNA sponge, and then miR-487a targeted the 3-UTR of hypoxia-inducible factor-1alpha (HIF-1alpha). Moreover, HIF-1alpha could bind with the promoter of hexokinase II (HK2) and promoted its transcription. In conclusion, this finding illustrates the vital roles of circRNF20 via the circRNF20/ miR-487a/HIF-1alpha/HK2 axis in breast cancer progress and Warburg effect, providing an interesting insight for the BC tumorigenesis.
Other information
Title:

Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1alpha/HK2.

Journal: Cell Death Dis
Published: 2020/2/26
PubMed ID: 32094325