circRNA basic information
circBase ID: -
Name: hsa_circ_AP2A2
Synonym: -
Host Gene: hsa-miR-382-5p
 
 
 
Disease basic information
DO ID:
 255
DO name: hemangioma
Disease details: infantile hemangioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human hemangioma-derived endothelial cells (HemECs), human umbilical vein endothelial cells (HUVEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: VEGFA
Associated microRNA: hsa-miR-382-5p
Biological function: promote proliferation, colony formation, migration, and invasion
Molecular mechanism: regulating hsa-miR-382-5p/VEGFA axis
Survival: -
Supported No.:
 1
Description:

CircAP2A2 was confirmed to be highly expressed in IH. CircAP2A2 knockdown or miR-382-5p overexpression decreased the proliferation, colony formation, migration, and invasion of HemECs and HUVEC cells. CONCLUSION: CircAP2A2 could promote proliferation and invasion of IH by regulating miR-382-5p/VEGFA axis.
Other information
Title:

CircAP2A2 acts as a ceRNA to participate in infantile hemangiomas progression by sponging miR-382-5p via regulating the expression of VEGFA.

Journal: J Clin Lab Anal
Published: 2020/2/25
PubMed ID: 32091151