circRNA basic information
circBase ID: hsa_circ_0001449
Name: hsa_circ_ARHGAP10
Synonym: -
Host Gene: hsa-miR-124-3p, hsa-miR-32-5p
 
 
 
Disease basic information
DO ID:
 2316
DO name: brain ischemia
Disease details: cerebral ischemia
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: Osbpl5
Associated microRNA: hsa-miR-124-3p, hsa-miR-32-5p
Biological function: disturbs phosphatidylinositol homeostasis and AKT activity
Molecular mechanism: sponges hsa-miR-124-3p and hsa-miR-32-5p to promote Osbpl5 translation
Survival: -
Supported No.:
 1
Description:

RNA sequencing and RNA pull down analyses confirmed a competing endogenous RNA pathway in which circ_0001449 sponges miR-124-3p and miR-32-5p to promote Osbpl5 translation. Our data showed that circRNA_0001449 regulates membrane homeostasis via ORP5 and is involved in the AKT survival pathway.
Other information
Title:

CircRNA_0001449 disturbs phosphatidylinositol homeostasis and AKT activity by enhancing Osbpl5 translation in transient cerebral ischemia.

Journal: Redox Biol
Published: 2020/2/23
PubMed ID: 32086008