circRNA basic information
circBase ID: hsa_circ_0000092
Name: hsa_circ_RPL5
Synonym: -
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HCC cell lines (Hep3B, LM3, MHCC97L, SK-hep1, HepG2), normal human liver cell line (THLE-2), human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HN1
Associated microRNA: hsa-miR-338-3p
Biological function: promote proliferation, migration, invasion and angiogenesis
Molecular mechanism: competitively bind to hsa-miR-338-3p to up-regulate HN1 expression
Survival: -
Supported No.:
 1
Description:

The results of this study suggested that hsa_circ_0000092 impaired miR-338-3p-mediated HN1 inhibition to aggravate the development of HCC, indicating that hsa_circ_0000092 is a potential candidate marker and therapeutic target for HCC.
Other information
Title:

hsa_circ_0000092 promotes hepatocellular carcinoma progression through up-regulating HN1 expression by binding to microRNA-338-3p.

Journal: J Cell Mol Med
Published: 2020/2/23
PubMed ID: 32077624