circRNA basic information
circBase ID: -
Name: hsa_circ_PUM1
Synonym: circ_PUM1
Host Gene: hsa-miR-136
 
 
 
Disease basic information
DO ID:
 1380
DO name: endometrial cancer
Disease details: endometrial cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: endometrial cancer cell line (HEC_1B), human endometrial carcinoma cells (Ishikawa)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NOTCH3
Associated microRNA: hsa-miR-136
Biological function: promoted the proliferation, migration and invasion
Molecular mechanism: compete with hsa-miR-136, leading to up-regulation of NOTCH3
Survival: -
Supported No.:
 2
Description:

Circ_PUM1 is capable of binding to miR-136, and up-regulating its target gene NOTCH3, which can be reversed by overexpression of miR-136. Circ_PUM1 can compete with miR-136, leading to up-regulation of NOTCH3, and thereby promote the development of endometrial cancer.
Other information
Title:

Circ_PUM1 promotes the development of endometrial cancer by targeting the miR-136/NOTCH3 pathway.

Journal: J Cell Mol Med
Published: 2020/2/20
PubMed ID: 32073729