circRNA basic information
circBase ID: hsa_circ_0003028
Name: hsa_circ_FUT8
Synonym: -
Host Gene: hsa-miR-570-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human urothelial cell line (SV-HUC-1), human BCa cell lines (T24, UM-UC-3)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: KLF10
Associated microRNA: hsa-miR-570-3p
Biological function: inhibited the migration and invasion of BCa cell lines in vitro and LN metastasis in vivo
Molecular mechanism: promoted the expression of KLF10 by competitively sponging hsa-miR-570-3p
Survival: better
Supported No.:
 1
Description:

circFUT8 functions as a tumor suppressor in BCa cells by targeting the miR-570-3p/KLF10 axis and may serve as a potential biomarker and therapeutic target for the management of BCa patients with LN metastasis.
Other information
Title:

circRNA circFUT8 Upregulates Krupple-like Factor 10 to Inhibit the Metastasis of Bladder Cancer via Sponging miR-570-3p.

Journal: Mol Ther Oncolytics
Published: 2020/2/20
PubMed ID: 32072011