circRNA basic information
circBase ID: hsa_circ_0001283
Name: -
Synonym: circRNA-0001283
Host Gene: hsa-miR-187
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MCF-7, MDA-MB-231, MDA-MB-468 MDA-MB-453, MCF-10A
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: HIPK3
Associated microRNA: hsa-miR-187
Biological function: suppressed cell viability and invasion, and induced apoptosis
Molecular mechanism: positively regulated HIPK3 expression by sponging hsa-miR-187
Survival: -
Supported No.:
 1
Description:

Ectopic expression of circRNA-0001283 remarkably suppressed cell viability and invasion, and induced apoptosis in breast cancer cells. Furthermore, circRNA-0001283 bound to miR-187 and decreased the expression of miR-187, which resulted in inhibition in cell growth and invasion. Finally, we showed that circRNA-0001283 positively regulated HIPK3 expression by sponging miR-187.
Other information
Title:

Circular RNA-0001283 Suppresses Breast Cancer Proliferation and Invasion via MiR-187/HIPK3 Axis.

Journal: Med Sci Monit
Published: 2020/2/19
PubMed ID: 32066649