circRNA basic information
circBase ID: hsa_circ_0075804
Name: -
Synonym: circ-0075804
Host Gene: -
 
 
 
Disease basic information
DO ID:
 768
DO name: retinoblastoma
Disease details: retinoblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human RB cell lines (Y79, SO_Rb50, WERI_Rb_1, HXO_ Rb44), human retinal capillary endothelial cells (HRCEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F3, HNRNPK
Associated microRNA: -
Biological function: facilitated cell proliferation and suppressed cell apoptosis
Molecular mechanism: combining HNRNPK to improve the stability of E2F3
Survival: -
Supported No.:
 3
Description:

circ-0075804 promotes the proliferation of RB via combining HNRNPK to improve the stability of E2F3, which brings new light for treating RB.
Other information
Title:

Circular RNA (circ-0075804) promotes the proliferation of retinoblastoma via combining heterogeneous nuclear ribonucleoprotein K (HNRNPK) to improve the stability of E2F transcription factor 3 E2F3.

Journal: J Cell Biochem
Published: 2020/2/18
PubMed ID: 32065448