circRNA basic information
circBase ID: -
Name: hsa_circ_CRIM1
Synonym: -
Host Gene: hsa-miR-422a
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NPC cell lines (S18, S26)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXQ1
Associated microRNA: hsa-miR-422a
Biological function: promoted NPC cell metastasis and EMT
Molecular mechanism: competitively bound to hsa-miR-422a and prevented the suppressive effects of hsa-miR-422a on its target gene FOXQ1
Survival: poor
Supported No.:
 2
Description:

circCRIM1 competitively bound to miR-422a and prevented the suppressive effects of miR-422a on its target gene FOXQ1, which finally led to NPC metastasis, EMT and docetaxel chemoresistance.
Other information
Title:

Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1.

Journal: Mol Cancer
Published: 2020/2/18
PubMed ID: 32061262