circRNA basic information
circBase ID: hsa_circ_0006156
Name: hsa_circ_FNDC3B
Synonym: -
Host Gene: hsa-miR-1178
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human PTC cell lines (K1, IHH-4, BCPAP, TPC-1), human thyroid follicular epithelial cells (Nthy-ori 3-1)
circRNA-disease information
Detected method:
Q
S
M
Detected method confidence High
Expression pattern:
UP
Associated gene: TLR4
Associated microRNA: hsa-miR-1178
Biological function: promoted the proliferation and Inhibits Apoptosis
Molecular mechanism: circFNDC3B/hsa-miR-1178/Toll-like receptor 4 (TLR4) axis
Survival: -
Supported No.:
 1
Description:

our study demonstrated that circFNDC3B modulates PTC progression through the miR-1178/TLR4 pathway. Our findings indicated that circFNDC3B may serve as a promising therapeutic target for the treatment of PTC patients.
Other information
Title:

Circular RNA Profiling Reveals Exosomal circ_0006156 as a Novel Biomarker in Papillary Thyroid Cancer.

Journal: Mol Ther Nucleic Acids
Published: 2020/2/16
PubMed ID: 32059339