circRNA basic information
circBase ID: -
Name: hsa_circ_Ttc3
Synonym: -
Host Gene: hsa-miR-449a
 
 
 
Disease basic information
DO ID:
 8717
DO name: decubitus ulcer
Disease details: pressure ulcer
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: nuclear factor kappa-B (NF-kappaB) and phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) pathways
Associated microRNA: hsa-miR-449a
Biological function: raised viability and reduced apoptosis
Molecular mechanism: activated nuclear factor kappa-B (NF-kappaB) and phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) pathways via downregulating hsa-miR-449a.
Survival: -
Supported No.:
 1
Description:

Our data suggested that circ-Ttc3 alleviated hypoxic injury and activated NF-kappaB and PI3K/AKT pathways by downregulating miR-449a in HaCaT cells.
Other information
Title:

Circular RNA circ-Ttc3 protects HaCaT cells from hypoxic injury by downregulation of miR-449a.

Journal: IUBMB Life
Published: 2020/2/12
PubMed ID: 32043754