circRNA basic information
circBase ID: hsa_circ_0000140
Name: -
Synonym: circRNA_0000140
Host Gene: hsa-miR-31
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human oral keratinocyte cells (HOK), human OSCC cell lines (Cal-27, SCC-25, SCC-9, HSC-3)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: LATS2
Associated microRNA: hsa-miR-31
Biological function: suppressed cell proliferation, migration, and invasion, and facilitated cell apoptosis
Molecular mechanism: bind with hsa-miR-31 and up-regulate its target gene LATS2
Survival: -
Supported No.:
 2
Description:

mechanistic studies showed that circ_0000140 could bind with miR-31 and up-regulate its target gene LATS2, thus affecting OSCC cellular EMT. Our findings demonstrated the roles of circ_0000140 in OSCC tumorigenesis as well as in metastasis, and circ_0000140 exerts its tumor-suppressing effect through miR-31/LATS2 axis of Hippo signaling pathway in OSCC.
Other information
Title:

circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway.

Journal: Cell Death Dis
Published: 2020/2/12
PubMed ID: 32041942