circRNA basic information
circBase ID: -
Name: hsa_circ_NR3C1
Synonym: -
Host Gene: hsa-miR-382-5p
 
 
 
Disease basic information
DO ID:
 10871
DO name: age related macular degeneration
Disease details: age-related macular degeneration
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: PTEN/AKT/mTOR Signaling Pathway
Associated microRNA: hsa-miR-382-5p
Biological function: -
Molecular mechanism: circNR3C1 acted as an endogenous microRNA-382-5p (hsa-miR-382-5p) sponge to sequester its activity
Survival: -
Supported No.:
 1
Description:

circNR3C1 prevents AMD progression and protects RPE by directly sponging miR-382-5p to block its interaction with PTEN and subsequently blocks the AKT/mTOR pathway. Pharmacological circNR3C1 supplementations are promising therapeutic options for atrophic AMD.
Other information
Title:

Circular Noncoding RNA NR3C1 Acts as a miR-382-5p Sponge to Protect RPE Functions via Regulating PTEN/AKT/mTOR Signaling Pathway.

Journal: Mol Ther
Published: 2020/2/6
PubMed ID: 32017889