circRNA basic information
circBase ID: hsa_circ_0016347
Name: hsa_circ_KCNH1
Synonym: -
Host Gene: hsa-miR-214
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human osteosarcoma cell lines (Saos-2, MG63), human osteoblast cell line hFOB (OB3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: caspase-1
Associated microRNA: hsa-miR-214
Biological function: promotes cell proliferation, migration, and invasion
Molecular mechanism: circ-0016347 was identified as a sponge of hsa-miR-214 that upregulated the expression of caspase-1, which is the functional target of hsa-miR-214.
Survival: poor
Supported No.:
 2
Description:

We demonstrated that circ-0016347 acted as a positive regulator in osteosarcoma cells proliferation and invasion.
Other information
Title:

Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells.

Journal: Oncotarget
Published: 2017/4/21
PubMed ID: 28424426