circRNA basic information
circBase ID: hsa_circ_0007623
Name: hsa_circ_ZNF432
Synonym: -
Host Gene: hsa-miR-297
 
 
 
Disease basic information
DO ID:
 1287
DO name: cardiovascular system disease
Disease details: myocardial ischemia
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: VEGFA
Associated microRNA: hsa-miR-297
Biological function: promote cell proliferation, migration, and angiogenesis
Molecular mechanism: acts as a sponge of microRNA-297
Survival: -
Supported No.:
 1
Description:

functional experiments revealed hsa_circ_0007623 silencing could up-regulate miR-297 and down-regulate VEGFA expression, and reduce cell proliferation, migration, and angiogenesis. We concluded that hsa_circ_0007623 can bind to miR-297, promote cardiac repair after acute myocardial ischemia, and protect cardiac function.
Other information
Title:

The circular RNA hsa_circ_0007623 acts as a sponge of microRNA-297 and promotes cardiac repair.

Journal: Biochem Biophys Res Commun
Published: 2020/1/25
PubMed ID: 31973814