circRNA basic information
circBase ID: -
Name: hsa_circ_RSF1
Synonym: -
Host Gene: hsa-miR-146a-5p
 
 
 
Disease basic information
DO ID:
 409
DO name: liver disease
Disease details: radiation-induced liver disease
Species: human
Species details: human
Sample type: cell line
Sample type details: human hepatic stellate cell line (LX2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RAC1
Associated microRNA: hsa-miR-146a-5p
Biological function: promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell
Molecular mechanism: increased RAC1 expression by acting as hsa-miR-146a-5p sponge to inhibit hsa-miR-146a-5p activity
Survival: -
Supported No.:
 1
Description:

Enforced expression of circRSF1 increased RAC1 expression by acting as miR-146a-5p sponge to inhibit miR-146a-5p activity, and thus enhanced the cell viability, and promoted inflammatory and fibrotic phenotype of irradiated LX2 cells.

Other information
Title:

Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p.

Journal: J Cell Physiol
Published: 2020/1/22
PubMed ID: 31960423