circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circRNA_002178
Host Gene: hsa-miR-328-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: immortalized human mammary epithelial cell line (MCF_10A), breast cancer cell lines (BT549, MCF_7, MDA_MB_231, T47D), human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: COL1A1
Associated microRNA: hsa-miR-328-3p
Biological function: promote in cell viability, energy metabolism and tube formation ability
Molecular mechanism: bind to hsa-miR-328-3p and down-regulated its expression
Survival: -
Supported No.:
 1
Description:

Hsa_circRNA_002178 could competitively bind to miR-328-3p and down-regulated its expression. Restoration of miR-328-3p eliminated the tumour-promoting effects of hsa_circRNA_002178. COL1A1, as a target of miR-328-3p, could be up-regulated by overexpression of hsa_circRNA_002178. In vivo experiments further confirmed the inhibition of tumour growth and inflammation by silencing hsa_circRNA_002178 or up-regulating miR-328-3p.
Other information
Title:

Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA-328-3p-mediated inhibition of COL1A1.

Journal: J Cell Mol Med
Published: 2020/1/21
PubMed ID: 31957232