circRNA basic information
circBase ID: -
Name: hsa_circ_ZDHHC20
Synonym: -
Host Gene: hsa-miR-144
 
 
 
Disease basic information
DO ID:
 10591
DO name: pre-eclampsia
Disease details: preeclampsia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human extravillous trophoblast cells (HTR-8/SVneo)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: GRHL2
Associated microRNA: hsa-miR-144
Biological function: represses the proliferation, migration and invasion
Molecular mechanism: acting as a hsa-miR-144 sponge
Survival: -
Supported No.:
 1
Description:

Our study suggested that a high level of circZDHHC20 inhibited the proliferation, migration, and invasion in trophoblast cells at least partially through sponging miR-144 and up-regulating GRHL2, providing a novel mechanism of PE pathogenesis.
Other information
Title:

CircZDHHC20 represses the proliferation, migration and invasion in trophoblast cells by miR-144/GRHL2 axis.

Journal: Cancer Cell Int
Published: 2020/1/21
PubMed ID: 31956297