circRNA basic information
circBase ID: hsa_circ_0089477
Name: hsa_circ_CAMSAP1
Synonym: -
Host Gene: hsa-miR-328-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CRC cancer cell lines (HT29, SW480, HCT116, SW620, Lovo, SW480, DLD1, Caco2, KM12, RKO, HCT15), human normal colonic epithelial cells (NCM460)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F1
Associated microRNA: hsa-miR-328-5p
Biological function: promotes tumor growth
Molecular mechanism: circCAMSAP1 acted as a sponge for hsa-miR-328-5p and abrogated its suppression on transcription factor E2F1.
Survival: poor
Supported No.:
 2
Description:

Our data indicated an essential role of the circCAMSAP1/miR-328-5p/E2F1 axis in the progression of CRC, which implied that circCAMSAP1 could serve as a diagnostic and prognostic biomarker as well as a potential therapeutic target for CRC.
Other information
Title:

circCAMSAP1 Promotes Tumor Growth in Colorectal Cancer via the miR-328-5p/E2F1 Axis.

Journal: Mol Ther
Published: 2020/1/18
PubMed ID: 31951832