circRNA basic information
circBase ID: -
Name: hsa_circ_CCND1
Synonym: -
Host Gene: hsa-miR-646
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: LSCC cell lines (AMC_HN_8, Hep_2, LSC_1, TU212, TU177, TU686, SCC10A), normal NP_69 cells, 293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HuR
Associated microRNA: hsa-miR-646
Biological function: promote proliferation
Molecular mechanism: act as an effective sponge for hsa-miR-646
Survival: -
Supported No.:
 2
Description:

circ-CCND1 physically bound to human antigen R (HuR) protein to enhance CCND1 mRNA stability; on the other hand, circ-CCND1 could act as an effective sponge for miR-646 to alleviate the repression of miR-646 on CCND1 mRNA. As a result, circ-CCND1 post-transcriptionally elevated CCND1 expression via coordinated avoidance of CCND1 mRNA decay, thereby promoting LSCC tumorigenesis.
Other information
Title:

circRNA circ-CCND1 promotes the proliferation of laryngeal squamous cell carcinoma through elevating CCND1 expression via interacting with HuR and miR-646.

Journal: J Cell Mol Med
Published: 2020/1/18
PubMed ID: 31951319