circRNA basic information
circBase ID: hsa_circ_0063809
Name: hsa_circ_CELSR1
Synonym: -
Host Gene: hsa-miR-1252
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ovarian carcinoma cell lines (SKOV3, HeyA-8), normal ovarian epithelial cell line (IOSE-80)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXR2
Associated microRNA: hsa-miR-1252
Biological function: contributes to paclitaxel resistance of ovarian cancer cells
Molecular mechanism: Regulating FOXR2 Expression via hsa-miR-1252
Survival: -
Supported No.:
 3
Description:

We explored the specific mechanisms of PTX resistance and tumor progress of ovarian cancer due to circCELSR1; presented the circCELSR1-miR-1252-FOXR2 axis and its role in ovarian cancer drug sensitivity and progression; and suggest that the results may provide an experimental basis for clinical application.
Other information
Title:

circCELSR1 (hsa_circ_0063809) Contributes to Paclitaxel Resistance of Ovarian Cancer Cells by Regulating FOXR2 Expression via miR-1252.

Journal: Mol Ther Nucleic Acids
Published: 2020/1/17
PubMed ID: 31945729