circRNA basic information
circBase ID: -
Name: hsa_circ_NOTCH1
Synonym: circ-NOTCH1
Host Gene: hsa-miR-449c-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal gastric mucosa epithelium (GES_1), GC cells (AGS, BGC_823, MGC_803, SGC_7901, MKN_ 45)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MYC/NOTCH1
Associated microRNA: hsa-miR-449c-5p
Biological function: promoted metastasis and stemness
Molecular mechanism: sponging hsa-miR-449c-5p
Survival: -
Supported No.:
 3
Description:

circ-NOTCH1 promoted metastasis and stemness in GC by targeting miR-449c-5p/MYC/NOTCH1 axis, suggesting the possibility of circ-NOTCH1 as a therapeutic marker for GC.
Other information
Title:

miR-449c-5p availability is antagonized by circ-NOTCH1 for MYC-induced NOTCH1 upregulation as well as tumor metastasis and stemness in gastric cancer.

Journal: J Cell Biochem
Published: 2020/1/17
PubMed ID: 31943342