circRNA basic information
circBase ID: -
Name: hsa_circ_RHOBTB3
Synonym: -
Host Gene: hsa-miR-654-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human GC cell lines (AGS, HGC27, MKN45)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: p21
Associated microRNA: hsa-miR-654-3p
Biological function: decreased proliferation
Molecular mechanism: as competing endogenous RNA (ceRNA) for hsa-miR-654-3p, which could contribute to growth inhibition of GC through activating p21 signaling pathway
Survival: better
Supported No.:
 2
Description:

Taken together, this study revealed that circRHOBTB3 might function as competing endogenous RNA (ceRNA) for miR-654-3p, which could contribute to growth inhibition of GC through activating p21 signaling pathway. Our data suggested that circRHOBTB3 would serve as a novel promising diagnosis marker and therapeutic target for GC.
Other information
Title:

Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth.

Journal: J Exp Clin Cancer Res
Published: 2020/1/14
PubMed ID: 31928527