circRNA basic information
circBase ID: hsa_circ_0000370
Name: hsa_circ_FLI1
Synonym: -
Host Gene: hsa-miR-1299
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: AML cell lines (HL-60, THP-1, U937, K-562, MV4-11)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: S100A7A
Associated microRNA: hsa-miR-1299
Biological function: increases cell viability and inhibits apoptosis
Molecular mechanism: we suggest that the promoting effects of circ_0000370 on the progression of FLT3-ITD(+) AML might be relevant to the inhibition of hsa-miR-1299 and the upregulation of S100A7A.
Survival: -
Supported No.:
 1
Description:

We suggest that the promoting effects of circ_0000370 on the progression of FLT3-ITD+ AML might be relevant to the inhibition of miR-1299 and the upregulation of S100A7A.
Other information
Title:

A novel circular RNA (hsa_circ_0000370) increases cell viability and inhibits apoptosis of FLT3-ITD-positive acute myeloid leukemia cells by regulating miR-1299 and S100A7A.

Journal: Biomed Pharmacother
Published: 2020/1/11
PubMed ID: 31919040