circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-29a
 
 
 
Disease basic information
DO ID:
 114
DO name: heart disease
Disease details: hypoxia-pretreated cardiomyocytes
Species: human
Species details: human
Sample type: cell line
Sample type details: primary cultures of neonatal mouse CMs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF-1
Associated microRNA: hsa-miR-29a
Biological function: -
Molecular mechanism: circHIPK3 acted as an endogenous hsa-miR-29a sponge to sequester and inhibit hsa-miR-29a activity, which led to increased IGF-1 expression.
Survival: -
Supported No.:
 4
Description:

circHIPK3 in HPC-exos plays a role in CMVECs under oxidative conditions through miR-29a-mediated IGF-1 expression, leading to a decrease in oxidative stress-induced CMVECs dysfunction.

Other information
Title:

Exosomal circHIPK3 Released from Hypoxia-Pretreated Cardiomyocytes Regulates Oxidative Damage in Cardiac Microvascular Endothelial Cells via the miR-29a/IGF-1 Pathway.

Journal: Oxid Med Cell Longev
Published: 2019/12/31
PubMed ID: 31885817