circRNA basic information
circBase ID: hsa_circ_0006948
Name: hsa_circ_FNDC3B
Synonym: -
Host Gene: hsa-miR-490-3p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: ESCC cells (TE-1, KYSE30, TE-7, TE-13, KYSE150 cell lines), normal epithelial esophageal cells (HEEC cell line)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGA2
Associated microRNA: hsa-miR-490-3p
Biological function: promote cell proliferation, migration and invasion
Molecular mechanism: induce EMT by enhancing HMGA2 by sponging hsa-miR-490-3p
Survival: -
Supported No.:
 4
Description:

In conclusion, hsa_circ_0006948 was overexpressed in ESCC tissues and promoted cancer progression, and it could induce EMT by enhancing HMGA2 by sponging miR-490-3p, suggesting that hsa_circ_0006948 could be a biomarker for ESCC.
Other information
Title:

Hsa_circ_0006948 enhances cancer progression and epithelial-mesenchymal transition through the miR-490-3p/HMGA2 axis in esophageal squamous cell carcinoma.

Journal: Aging (Albany NY)
Published: 2019/12/28
PubMed ID: 31881015