circRNA basic information
circBase ID: hsa_circ_0003998
Name: -
Synonym: circ-0003998
Host Gene: hsa-miR-197-3p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human osteoblast cell line (hFOB), human osteosarcoma cell lines (143B, U-2OS, MG-63, Saos-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF10
Associated microRNA: hsa-miR-197-3p
Biological function: promotes cell proliferative ability and invasiveness
Molecular mechanism: up-regulates the expression of KLF10 by binding to hsa-miR-197-3p
Survival: poor
Supported No.:
 1
Description:

Circ-0003998 plays a vital role in promoting the development of osteosarcoma, whose high expression can predict poor clinical prognosis. Circ-0003998 is highly expressed in osteosarcoma tissues and cell lines. The down-regulation of its level can significantly inhibit the proliferative ability and invasiveness of osteosarcoma cells. Meanwhile, circ-0003998 up-regulates the expression of KLF10 by binding to miR-197-3p, thereby promoting osteosarcoma cell growth and invasion, and accelerating the progression of osteosarcoma.
Other information
Title:

Circ-0003998 promotes cell proliferative ability and invasiveness by binding to miR-197-3p in osteosarcoma.

Journal: Eur Rev Med Pharmacol Sci
Published: 2019/12/21
PubMed ID: 31858530