circRNA basic information
circBase ID: -
Name: hsa_circ_MTHFD2
Synonym: circ MTHFD2
Host Gene: hsa-miR-124
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: human gastric cancer cells (MGC-803)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MDR-1
Associated microRNA: hsa-miR-124
Biological function: enhancing the drug resistance
Molecular mechanism: increased protein expression of MDR-1
Survival: -
Supported No.:
 1
Description:

Circ MTHFD2 directly binds to miR-124 through the molecular sponge effect. This may induce increased protein expression of MDR-1, ultimately enhancing the drug resistance of MGC-803/MTA cells.
Other information
Title:

Effect of circ MTHFD2 on resistance to pemetrexed in gastric cancer through regulating expression of miR-124.

Journal: Eur Rev Med Pharmacol Sci
Published: 2019/12/17
PubMed ID: 31841184