circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: cir-ITCH, circ-ITCH
Host Gene: hsa-miR-17-5p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human PC cell lines (C4-2, LNCaP, DU145, 22Rv1, PC-3, VcaP), human prostate epithelial cell line (RWPE-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HOXB13
Associated microRNA: hsa-miR-17-5p
Biological function: suppresses proliferation
Molecular mechanism: CircITCH acted as a sponge of hsa-miR-17-5p to increase HOXB13 gene expression.
Survival: better
Supported No.:
 2
Description:

CircITCH promoted prostate cancer progression by regulating the HOXB13/miR-17-5p axis, and circITCH have a potential usage as therapeutic target for PC tumors.
Other information
Title:

Circular RNA ITCH suppressed prostate cancer progression by increasing HOXB13 expression via spongy miR-17-5p.

Journal: Cancer Cell Int
Published: 2019/12/13
PubMed ID: 31827402