circRNA basic information
circBase ID: hsa_circ_0014130
Name: hsa_circ_PIP5K1A
Synonym: -
Host Gene: hsa-miR-566
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: cell lines of lung cancer (PC9, H1299, A549, HCC827, BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TWIST1
Associated microRNA: hsa-miR-566
Biological function: promotes the invasion and proliferation
Molecular mechanism: targeting hsa-miR-566 to enhance the expression of TWIST1
Survival: -
Supported No.:
 1
Description:

The hsa_circ_0014130 promotes the invasion and proliferation of lung cancer cells by targeting hsa-miR-566 to enhance the expression of TWIST1, and its expression level can be significantly inhibited by the small molecule inhibitor SB-431542, which significantly inhibits the proliferation and invasion of lung cancer cells. Therefore,hsa_circ_0014130 is a potential lung cancer treatment target.
Other information
Title:

[Expression of circular RNA hsa_circ_0014130 in lung adenocarcinoma cell lines and its effect on proliferation and invasion of lung adenocarcinoma cell line].

Journal: Zhonghua Bing Li Xue Za Zhi
Published: 2019/12/11
PubMed ID: 31818066