circRNA basic information
circBase ID: -
Name: mmu_circ_FOXO3
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 114
DO name: heart disease
Disease details: cardiac senescence
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ID-1, E2F1, FAK, HIF1a
Associated microRNA: -
Biological function: promotes cardiac senescence
Molecular mechanism: ID-1, E2F1, FAK, and HIF1alpha interact with circ-Foxo3
Survival: -
Supported No.:
 2
Description:

We also found that silencing circ-Foxo3 inhibited senescence of mouse embryonic fibroblasts and that ectopic expression of circ-Foxo3 induced senescence.
Other information
Title:

Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses.

Journal: Eur Heart J
Published: 2016/2/14
PubMed ID: 26873092