circRNA basic information
circBase ID: -
Name: hsa_circ_SMAD7
Synonym: circ-SMAD7
Host Gene: -
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human glioma cell lines (U87, U373, U251, T98), normal human astrocyte cell line
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PCNA
Associated microRNA: -
Biological function: promoted glioma cell proliferation and metastasis
Molecular mechanism: upregulating PCNA
Survival: -
Supported No.:
 1
Description:

Our study suggests that circ-SMAD7 promotes proliferation and metastasis of glioma via upregulating PCNA. Circ-SMAD7/ PCNA might be a novel therapeutic strategy in glioma.
Other information
Title:

Circular RNA circ-SMAD7 promoted glioma cell proliferation and metastasis by upregulating PCNA.

Journal: Eur Rev Med Pharmacol Sci
Published: 2019/12/5
PubMed ID: 31799673