circRNA basic information
circBase ID: -
Name: mmu_circ_Nr1h4
Synonym: -
Host Gene: mmu-miR-155-5p
 
 
 
Disease basic information
DO ID:
 10763
DO name: hypertension
Disease details: hypertension
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: Far1
Associated microRNA: mmu-miR-155-5p
Biological function: -
Molecular mechanism: acts as a competing endogenous RNA for mmu-miR-155-5p, leading to regulation of its target gene Far1
Survival: -
Supported No.:
 1
Description:

the silencing of circNr1h4 or overexpression of miR-155-5p significantly decreased Far1 levels and increased reactive oxygen species. Mechanistic investigations indicated that circNr1h4 acts as a competing endogenous RNA for miR-155-5p, leading to regulation of its target gene Far1.

Other information
Title:

CircNr1h4 regulates the pathological process of renal injury in salt-sensitive hypertensive mice by targeting miR-155-5p.

Journal: J Cell Mol Med
Published: 2019/11/30
PubMed ID: 31782248