circRNA basic information
circBase ID: hsa_circ_0000654
Name: hsa_circ_CHD2
Synonym: -
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ESCC cell lines (TE-1, KYSE410, TE-13, ECA-109, KYSE450), normal esophageal epithelial cell line (HEEC cells)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IL-6, STAT3
Associated microRNA: hsa-miR-149-5p
Biological function: promotes the Proliferation and Migration
Molecular mechanism: Circ_0000654 was identified as a sponge of hsa-miR-149-5p and facilitated ESCC progression by indirectly activating the IL-6/STAT3 signaling pathway
Survival: -
Supported No.:
 2
Description:

circ_0000654 functions as an oncogenic circRNA in ESCC and accelerates ESCC progression via adsorbing miR-149-5p and activating the IL-6/STAT3 signaling pathway.
Other information
Title:

Circular RNA hsa_circ_0000654 promotes esophageal squamous cell carcinoma progression by regulating the miR-149-5p/IL-6/STAT3 pathway.

Journal: IUBMB Life
Published: 2019/11/30
PubMed ID: 31778020