circRNA basic information
circBase ID: -
Name: hsa_circ_TFCP2L1
Synonym: circ-TFCP2L1
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human TNBC cell lines (SUM1315, HCC1937, MDA-MB-231, MCF-10A)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: PAK1
Associated microRNA: hsa-miR-7
Biological function: promotes the Proliferation and Migration
Molecular mechanism: Sponging hsa-miR-7 and Inhibiting PAK1.
Survival: -
Supported No.:
 1
Description:

circ-TFCP2L1 was identified as a sponge of miR-7 functionally targeting PAK1 and further promoting the proliferation and migration of TNBC cells.
Other information
Title:

Circ-TFCP2L1 Promotes the Proliferation and Migration of Triple Negative Breast Cancer through Sponging miR-7 by Inhibiting PAK1.

Journal: J Mammary Gland Biol Neoplasia
Published: 2019/11/30
PubMed ID: 31776835