circRNA basic information
circBase ID: -
Name: hsa_circ_PWWP2A
Synonym: circ-PWWP2A
Host Gene: -
 
 
 
Disease basic information
DO ID:
 409
DO name: liver disease
Disease details: hepatic fibrosis
Species: human
Species details: human
Sample type: cell line
Sample type details: human HSC line cells (LX2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes hepatic fibrosis
Molecular mechanism: sponging hsa-miR-203 and hsa-miR-223
Survival: -
Supported No.:
 1
Description:

circ-PWWP2A is the common downstream reactor of TGF-beta and LPS in HSC activation, and that circ-PWWP2A plays a critical role in hepatic fibrogenesis via sponging miR-203 and miR-223.
Other information
Title:

TGF-beta- and lipopolysaccharide-induced upregulation of circular RNA PWWP2A promotes hepatic fibrosis via sponging miR-203 and miR-223.

Journal: Aging (Albany NY)
Published: 2019/11/14
PubMed ID: 31719209