circRNA basic information
circBase ID: -
Name: hsa_circ_ASH2L
Synonym: circ-ASH2L
Host Gene: hsa-miR-34a
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: pancreatic ductal adenocarcinoma cell lines (AsPC-1, BxPC-3, Capan-1, Hs 766_T, PANC-1, SW1990)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Notch1
Associated microRNA: hsa-miR-34a
Biological function: promoted tumor invasion, proliferation and angiogenesis
Molecular mechanism: regulating hsa-miR-34a, thus regulate Notch 1 expression
Survival: poor
Supported No.:
 1
Description:

circ-ASH2L play an important role in tumor invasion, and high circ-ASH2L may be a useful marker of PDAC diagnosis or progression.
Other information
Title:

Circ-ASH2L promotes tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma.

Journal: J Exp Clin Cancer Res
Published: 2019/11/14
PubMed ID: 31718694