circRNA basic information
circBase ID: -
Name: hsa_circ_PRMT5
Synonym: circ-PRMT5
Host Gene: hsa-miR-145, hsa-miR-1304
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: GC cell lines (AGS, MKN-28, MKN45, BGC823, MGC803, SGC7901), normal human gastric epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MYC
Associated microRNA: hsa-miR-145, hsa-miR-1304
Biological function: promote cell proliferation, invasion
Molecular mechanism: sponged hsa-miR-145/hsa-miR-1304 to upregulate MYC expression and GC development
Survival: poor
Supported No.:
 1
Description:

High circ-PRMT5 expression may provide a poor prognostic indicator of survival in GC patients and targeting circ-PRMT5/miR-145/miR-1304/MYC axis may be a novel therapeutic strategy for GC.
Other information
Title:

Circ-PRMT5 promotes gastric cancer progression by sponging miR-145 and miR-1304 to upregulate MYC.

Journal: Artif Cells Nanomed Biotechnol
Published: 2019/11/9
PubMed ID: 31701767