circRNA basic information
circBase ID: hsa_circ_0001546
Name: hsa_circ_FAM114A2
Synonym: -
Host Gene: hsa-miR-421
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ATM, Chk2
Associated microRNA: hsa-miR-421
Biological function: inhibit the chemoresistance of gastric cancer cells
Molecular mechanism: sponges hsa-miR-421 to upregulate the expression level of ATM and inhibit the proliferation and chemoresistance through the activation of the ATM/Chk2/p53-dependent pathway
Survival: better
Supported No.:
 2
Description:

circ_0001546 sponges miR-421 to upregulate the expression level of ATM and inhibit the proliferation and chemoresistance through the activation of the ATM/Chk2/p53-dependent pathway.
Other information
Title:

Hsa_circ_0001546 acts as a miRNA-421 sponge to inhibit the chemoresistance of gastric cancer cells via ATM/Chk2/p53-dependent pathway.

Journal: Biochem Biophys Res Commun
Published: 2019/11/2
PubMed ID: 31668372