circRNA basic information
circBase ID: -
Name: hsa_circ_FAM53B
Synonym: circ_FAM53B
Host Gene: hsa-miR-646, hsa-miR-647
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OC cells (HO8910, SKOV3, OVCAR3, A2780), normal cell line (IOSE80)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: VAMP2, MDM2
Associated microRNA: hsa-miR-646, hsa-miR-647
Biological function: accelerated the proliferation, migration, and invasion
Molecular mechanism: circ_FAM53B/miRNA_646/vesicle_associated membrane protein 2 (VAMP2) and circ_FAM53B/miRNA_647/mouse double minute 2 (MDM2)
Survival: poor
Supported No.:
 1
Description:

circ_FAM53B could be a competing endogenous RNA (ceRNA) to competitively sponge miR_646 and miR_647 to upregulate VAMP2 and MDM2 expression at the post_transcriptional level, thus mediating the cellular behaviors of OC cells.
Other information
Title:

Upregulation of circular RNA circ_FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR_646/VAMP2 and miR_647/MDM2 signaling pathways.

Journal: Oncol Rep
Published: 2019/10/23
PubMed ID: 31638250