circRNA basic information
circBase ID: -
Name: hsa_circ_FNDC3B
Synonym: -
Host Gene: hsa-miR-99a
 
 
 
Disease basic information
DO ID:
 4451
DO name: renal carcinoma
Disease details: renal carcinoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: JAK1, STAT3, MEK, ERK
Associated microRNA: hsa-miR-99a
Biological function: enhanced cell viability, colony and migration
Molecular mechanism: circFNDC3B negatively regulated hsa-miR-99aand circFNDC3B restrained the janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) and extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK pathways by hsa-miR-99a downregulation
Survival: -
Supported No.:
 1
Description:

Overexpression of circFNDC3B enhanced cell viability, colony formation and migration by miR-99a downregulation via JAK1/STAT3 and MEK/ERK pathways.
Other information
Title:

Circular RNA circFNDC3B protects renal carcinoma by miR-99a downregulation.

Journal: J Cell Physiol
Published: 2019/10/23
PubMed ID: 31637704