circRNA basic information
circBase ID: hsa_circ_0000448
Name: hsa_circ_GCN1L1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: temporomandibular joint osteoarthritis
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes TNF-alpha secretion
Molecular mechanism: -
Survival: -
Supported No.:
 2
Description:

circRNAs in TMJ synovial tissue participate in the progression of TMJOA and may become a potential therapeutic target. The highly up-regulated has_circ_0000448 probably promotes TNF-alpha secretion of synovium through CeRNA mechanism in TMJOA.
Other information
Title:

Expression profile of circular RNA s in TMJ osteoarthritis synovial tissues and potential functions of hsa_circ_0000448 with specific back-spliced junction.

Journal: Am J Transl Res
Published: 2019/10/22
PubMed ID: 31632516