circRNA basic information
circBase ID: -
Name: hsa_circ_RAPGEF5
Synonym: cRAPGEF5
Host Gene: hsa-miR-27a-3p
 
 
 
Disease basic information
DO ID:
 4451
DO name: renal carcinoma
Disease details: renal carcinoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TXNIP
Associated microRNA: hsa-miR-27a-3p
Biological function: inhibits the growth and metastasis
Molecular mechanism: cRAPGEF5 functions as a sponge of oncogenic hsa-miR-27a-3p, which targets the suppressor gene TXNIP. Interactions between hsa-miR-27a-3p and cRAPGEF5 or TXNIP were confirmed by dual-luciferase reporter assays
Survival: -
Supported No.:
 1
Description:

cRAPGEF5 plays a role in suppressing RCC via the miR-27a-3p/TXNIP pathway.
Other information
Title:

CircRNA cRAPGEF5 inhibits the growth and metastasis of renal cell carcinoma via the miR-27a-3p/TXNIP pathway.

Journal: Cancer Lett
Published: 2019/10/21
PubMed ID: 31629934