circRNA basic information
circBase ID: -
Name: hsa_circ_AF4
Synonym: -
Host Gene: hsa-miR-128-3p
 
 
 
Disease basic information
DO ID:
 0081037
DO name: mixed phenotype acute leukemia with MLL rearranged
Disease details: mll leukemia
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MLL-AF4
Associated microRNA: hsa-miR-128-3p
Biological function: promotes the proliferation
Molecular mechanism: circAF4 can act as a hsa-miR-128-3p sponge, thereby releasing its inhibition on MLL-AF4 expression.
Survival: -
Supported No.:
 1
Description:

the abnormal elevated expression of circAF4 regulates the cell growth via the circAF4/miR-128-3p/MLL-AF4 axis.
Other information
Title:

circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression.

Journal: J Hematol Oncol
Published: 2019/10/19
PubMed ID: 31623653