circRNA basic information
circBase ID: -
Name: hsa_circ_PLEKHM3
Synonym: -
Host Gene: hsa-miR-9
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: BRCA1, DNAJB6, KLF4, AKT1
Associated microRNA: hsa-miR-9
Biological function: inhibited cell growth, migration and epithelial-mesenchymal transition
Molecular mechanism: circPLEKHM3 sponged hsa-miR-9 to regulate the endogenous expression of BRCA1, DNAJB6 and KLF4, and consequently inactivate AKT1 signaling
Survival: -
Supported No.:
 2
Description:

circPLEKHM3 functions as a tumor suppressor in ovarian cancer cells by targeting the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis.
Other information
Title:

CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer.

Journal: Mol Cancer
Published: 2019/10/19
PubMed ID: 31623606