circRNA basic information
circBase ID: hsa_circ_0005105
Name: hsa_circ_SEC24A
Synonym: -
Host Gene: hsa-miR-26a
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: cell line
Sample type details: human chondrocytes-articular
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NAMPT
Associated microRNA: hsa-miR-26a
Biological function: promotes chondrocyte extracellular matrix degradation
Molecular mechanism: inhibit the expression of type II collagen and aggrecan, promote the expression of MMP-13 and ADAMTS-4, and the generation of PGE2, IL-6, and IL-8
Survival: -
Supported No.:
 3
Description:

Hsa_circ_0005105 can promote extracellular matrix (ECM) degradation by regulating the expression of miR-26a target NAMPT.
Other information
Title:

CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR-26a.

Journal: Cell Biol Int
Published: 2017/3/10
PubMed ID: 28276108