circRNA basic information
circBase ID: -
Name: hsa_circ_UHRF1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OSCC cell lines (SCC25, CAL27, SCC15, TSCCA)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promoted the proliferation, migration, invasion, and epithelial mesenchymal transformation (EMT)
Molecular mechanism: circUHRF1 acted as the sponge of hsa-miR-526b-5p, thereby positively regulating c-Myc. Transcription factor c-Myc could accelerate the transcription of TGF-beta1 and ESRP1. Moreover, splicing factor ESRP1 promoted the circularization and biogenesis of circUHRF1 by targeting the flanking introns, forming the circUHRF1/hsa-miR-526b-5p/c-Myc/TGF-beta1/ESRP1 feedback loop.
Survival: poor
Supported No.:
 1
Description:

circUHRF1 promoted the proliferation, migration, invasion, and epithelial mesenchymal transformation (EMT) in vitro and the tumor growth in vivo.
Other information
Title:

Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop.

Journal: Cell Death Differ
Published: 2019/10/2
PubMed ID: 31570856