circRNA basic information
circBase ID: -
Name: mmu_circ_FOXO3
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: mouse
Species details: mouse
Sample type: cell line
Sample type details: B16 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: CDK2, p21
Associated microRNA: -
Biological function: blocked cell cycle progression
Molecular mechanism: The formation of this circ-Foxo3-p21-CDK2 ternary complex arrested the function of CDK2 and blocked cell cycle progression
Survival: -
Supported No.:
 1
Description:

The circular RNA circ-Foxo3 was highly expressed in noncancer cells and were associated with cell cycle progression. Silencing endogenous circ-Foxo3 promoted cell proliferation.
Other information
Title:

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.

Journal: Nucleic Acids Res
Published: 2016/2/11
PubMed ID: 26861625