circRNA basic information
circBase ID: -
Name: hsa_circ_FOXO3
Synonym: -
Host Gene: hsa-miR-138-5p, hsa-miR-432-5p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-138-5p, hsa-miR-432-5p
Biological function: enhance cell proliferation and invasion
Molecular mechanism: increase expression of nuclear factor of activated T cells 5 (NFAT5) via sponging both hsa-miR-138-5p and hsa-miR-432-5p
Survival: -
Supported No.:
 1
Description:

tumor inhibition by circFOXO3 downregulation could be reversed by miR-138-5p/miR-432-5p inhibitors in GBM cells.
Other information
Title:

CircFOXO3 promotes glioblastoma progression by acting as a competing endogenous RNA for NFAT5.

Journal: Neuro Oncol
Published: 2019/9/11
PubMed ID: 31504797