circRNA basic information
circBase ID: -
Name: hsa_circ_AKT3
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: decreased the cell proliferation, radiation resistance
Molecular mechanism: competing with active phosphoinositide-dependent Kinase-1.
Survival: -
Supported No.:
 2
Description:

Circ-AKT3 encodes a 174 amino acid (aa) novel protein AKT3-174aa. AKT3-174aa competitively interacts with phosphorylated PDK1, reduces AKT-thr308 phosphorylation, and plays a negative regulatory role in modulating the PI3K/AKT signal intensity.
Other information
Title:

A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.

Journal: Mol Cancer
Published: 2019/9/1
PubMed ID: 31470874